Inflammation Atherosclerosis And Coronary Artery Disease Pdf

inflammation atherosclerosis and coronary artery disease pdf

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Inflammation, atherosclerosis, and coronary artery disease

Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between chronic infections and atherosclerosis triggered interest in a clinical association between these conditions. Various infectious microbes have been linked to atherosclerotic vascular disease in epidemiological studies. Identification of underlying pathophysiological mechanisms and experience with vaccination against various infectious agents has ushered a new avenue of efforts in the development of an anti-atherosclerotic vaccine. Studies in animal models have identified various innate and adaptive immune pathways in atherosclerosis.

Atherosclerosis is a multifactorial disease triggered and sustained by different risk factors such as dyslipidemia, arterial hypertension, diabetes mellitus, smoke, etc. Since a couple of decades, a pivotal role for inflammation in its pathogenesis has been recognized and proved at molecular levels, and already described in many animal models. Despite all this knowledge, due to the complexity of the specific inflammatory process subtending atherosclerosis and to the fact that inflammation is also a protective response against microorganisms, no anti-inflammatory therapy has been rendered available in the therapeutic armamentarium against atherosclerosis and vascular events till when canakinumab in the first ad-hoc randomized clinical trial RCT proved for the first time that targeting specifically inflammation lowers cardiovascular CV events. From the genetic side, in the 90's and early , several genetic markers in inflammatory pathway have been explored searching for an association with athero-thrombosis which gave seldom consistent results. Then, in the genomic era, plenty of genetic markers covering most of the genome have been analyzed at once without a priori information. The results coming from genome wide association studies GWAS have pinpointed some loci closed to inflammatory molecules consistently associated with atherosclerosis and CV consequences revamping the strict link between inflammation and atherosclerosis and suggesting some tailored target therapy. Whole-exome and whole-genome sequencing will come soon showing new and old loci associated with atherosclerosis suggesting new molecular targets or underlying which inflammatory pathway could be most attractive to target for blocking atherosclerosis even in its early stages.

Cardiovascular disease CVD remains the leading cause of mortality and morbidity worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with inflammation as one of its driving processes. Cardiovascular disease CVD remains the leading cause of mortality and morbidity worldwide, despite major improvements in treatment and outcomes. CVD is a group of diseases that effects the heart and blood vessels including coronary artery disease CAD , cerebrovascular disease, and peripheral artery disease [ 1 , 2 ]. CAD is characterized by the accumulation of atherosclerotic plaque in the coronary arteries and its major clinical consequence is an acute myocardial infarction MI [ 3 ]. Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, inflammatory cells, and fibrous elements in arterial plaques.

2018, Number 6

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Immune cells dominate early atherosclerotic lesions, their effector molecules accelerate progression of the lesions, and activation of inflammation can elicit acute coronary syndromes. This review highlights the role of inflammation in the pathogenesis of atherosclerotic CAD.


PDF | ecent research has shown that inflammation plays a key role in coronary artery disease (CAD) and other manifestations of.


Inflammation, atherosclerosis, and coronary artery disease

Key words:. Global, regional, and national age-sex specific all-cause and cause-specific mortality for cau of death, a systematic analysis for the Global Burden of Disease Study Lancet London, England [Internet] ; Circulation [Internet] ; 25

Our knowledge of the pathophysiology of atherosclerosis and the development of acute coronary syndrome ACS has progressed over the last few decades thanks to the large number of studies on the proliferation of smooth muscle cells, growth factors, and the biology of the vascular bed. The prominent role played by inflammation in the pathogenesis of atherosclerosis has become apparent over the last decade. The role of inflammation at the start of atherosclerotic processes and during their progression and in the complications present in the plaques has been well established through many clinical and experimental studies.

2018, Number 6

Research into inflammation, atherosclerosis and coronary artery disease, including observational studies, clinical trials, epidemiology, and advances in applied translational research. The supplement is intended to include overviews of new concepts in pathophysiology, natural history, diagnostic strategies, and treatment approaches. Article types include original clinical and basic research articles, case reports, commentaries, meeting reports, methodology, perspectives.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Lancet,


Request PDF | On Jan 1, , G.K. Hansson published Inflammation, atherosclerosis, and coronary artery disease | Find, read and cite all the research you.


Supplement Aims and Scope

Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart called coronary arteries. Plaque is made up of cholesterol deposits. Plaque buildup causes the inside of the arteries to narrow over time. This process is called atherosclerosis. It is sometimes called coronary heart disease or ischemic heart disease.

Однако он умел анализировать свои эмоции и не собирался позволить им отразиться на решении проблемы Цифровой крепости.

 Was passiert? - нервно спросил.  - Что происходит. Беккер не удостоил его ответом. - На самом деле я его не продала, - сказала Росио.  - Хотела это сделать, но она совсем еще ребенок, да и денег у нее не .

Развяжи, пока не явились агенты безопасности. - Они не придут, - сказала она безучастно. Хейл побледнел. - Что это .

Будь он менее самонадеян, он, конечно же, заглянул бы в энциклопедию и обнаружил, что это не что иное, как солевой осадок, оставшийся после высыхания древних морей. Как и все криптографы АНБ, Хейл зарабатывал огромные деньги, однако вовсе не стремился держать этот факт при. Он ездил на белом лотосе с люком на крыше и звуковой системой с мощными динамиками.

Coronary Artery Disease (CAD)

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